Selective serotonin norepinephrine re-uptake inhibitors (SSNRI) are a class of antidepressants that affect the neurotransmitters serotonin and norepinephrine. These type of antidepressants affect the levels of serotonin and norepinephrine in the brain which affect a person's mood. SSNRIs are used to treat major depression and neuropathic pain. They can also be used to treat anxiety, attention deficit hyperactivity disorder, obsessive-compulsive disorder (OCD), and some mood disorders.

An example of an SSNRI is Cymbalta (duloxetine).

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