Oculocerebral Syndrome with Hypopigmentation is also known as Cross-McKusick-Breen Syndrome, Cross Syndrome, Depigmentation-Gingival Fibromatosis-Microphthalmia, and Kramer Syndrome.
The symptoms of this congenital disorder include unusually lighter color of the skin and hair (silvery-gray), eye abnormalities (smallness of one or both eyes, corneal clouding, and nystagmus), involuntary muscle contraction, intellectual disability, sensitivity to light, abnormally large gums, and underdeveloped diaphragm. Oculocerebral syndrome is extremely rare as only around 15 cases have been reported in medical literature. Most of these cases were recorded to be within families. The treatments are symptomatic such as corrective glasses, gum surgery, and remedial education.