A Neuromodulator is any one of a number of naturally produced brain chenicals; serotonin, dopamine, histamine, acetycholine, and others, that affect the post-synaptic nerurons of the brain to create emotional states.

Neuromodulators are not quickly reabsorbed and remain active in the cerebrospinal fluid (fluid that surrounds and infuses the brain) for a considerable length of time thereby having long-term effects on mood and other physical and mental states.

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