Albright’s Hereditary Osteodystrophy (AHO)

Albright’s hereditary osteodystrophy (AHO) is a condition characterized by the body’s inability to respond to parathyroid hormone which regulates the calcium level in the blood. The signs and symptoms include full cheeks, short stature, obesity, bone formation under the skin, diminished function of sex organs, short fingers and toes, underdevelopment of teeth enamel, spasms of the extremities, and calcification of the choroid plexus (a brain part which produces cerebrospinal fluid). This rare genetic disorder was named after Fuller Albright, an American endocrinologist who first described it in 1942. The treatment usually focuses on regulating calcium, phosphorus, and vitamin D levels.

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